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Personal Docente e Investigador

Portada > Personal Docente e Investigador

IÑIGO LASA UZCUDUN
Catedrático Universidad

  • Departamento: CIENCIAS DE LA SALUD
  • Área de conocimiento: Microbiología
  • e-mail: ilasaATunavarra.es
  • Teléfono: 848422486 (ext. )
  • Ubicación  NAVARRABIOMED

Education and past positions

  • 1983-1988      B.Sc. Biology. University of Navarra. Spain
  • 1992               PhD thesis in Science, Universidad Autonoma de Madrid.     
  • 1995-1997      EU Postdoctoral fellow.Unité des interactions Bacteries-Celules. Institut Pasteur. France.
  • 1998 – 2008    Assistant Professor of Microbiology. Universidad Pública de Navarra 
  • 2008-present   Professor of Microbiology. Universidad Pública de Navarra.
  • 2010-2013      Director of Biotechnology center, Mutilva, Spain.
  • 2015-2022      Director of Navarrabiomed, Center of Biomedical Research, Pamplona. Spain
  • 2023-              Professor of Microbiology

Scientific Expertise

  • 2009-2010 Visiting scientist. Cold Spring Harbor Laboratory. USA 
  • 2013-2018 Head of the Management Board (MB) of the Biotechnology grant program of the Spanish Ministry
  • 2022- Associated Editor NPJ Biofilms and Microbiome
  • 2020- Associated Editor "Biofilms" journal

Distinctions, Prices 

2001 “Ortiz de Landazuri” award. Gobierno de Navarra, Spain

2005 “Jaime Ferran” award. Sociedad Española de Microbiología. Cáceres. Spain

2006 Research award on Basic Science of the Public University of Navarra. Spain

2019 Miembro electo de la Academia Europea de Microbiologia

Five selected publications (Members of the team are underlined)

  • Taglialegna A, Navarro S, Ventura S, Garnett JA, Matthews S, Penadés JR, Lasa I*,Valle J*. 2016. Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals. PLoS Pathog 12:e1005711.
  • Echeverz M, García B, Sabalza A, Valle J, Gabaldón T, Solano C, Lasa I. (2017). Lack of the PGA exopolysaccharide in Salmonellaas an adaptive trait for survival in the host. PLoS Genetics 13:e1006816.
  • Villanueva M, García B, Valle J, Ruiz de los Mozos I., Solano C, Marti M., Penades J.R., Toledo-Arana A., Lasa I.(2018). Sensory deprivation in Staphylococcus aureus. Nature Communications 9:523.
  • Sáenz-Lahoya, S. .....Lasa I. Noncontiguous operon is a genetic organization for coordinating bacterial gene expression. Proc National Acad Sci 116, 201812746 (2019).
  • Iturbe, P., Martín, A.S., Hamamoto, H., Marcet, M., Gabaldon, T., Solano, C., and Lasa, I. (2024). Noncontiguous operon atlas for the Staphylococcus aureus genome. microLife, uqae007. https://doi.org/10.1093/femsml/uqae007.
  • Rostøl, J.T., Quiles-Puchalt, N., Iturbe-Sanz, P., Lasa, Í., and Penadés, J.R. (2024). Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles. Nat. Microbiol., 1–13. https://doi.org/10.1038/s41564-024-01661-6.

Bibliometrics figures (h index citations) ORCID:  0000-0002-6625-9221, Research ID: F-2947-2011

·     Total articles in publication list: >128

·     Sum of the times cited: > 10200

·     h-index: 56 (scopus), 54 (web of science)

·     Last updated: 14/12/2024

Research interests 

Our laboratory investigates fundamental mechanisms of regulation of bacterial biofilm development with a focus on human pathogens. We are interested in understanding how signal transduction systems control the transition between planktonic and sessile lifestyles. We also study the composition of biofilm matrix and the function of these compounds during infection. In particular, we do research on basic principles of RNA overlapping transcription and its role in gene expression, on mechanisms of exopolysaccharide synthesis regulation and on how surface proteins of the biofilm matrix mediated intercellular adhesion and interactions with the host cells. Very recently, we have deconstructed the two-component signal transduction system of Staphylococcus aureus. In this study, we have generated fifteen S. aureusstrains, each containing just a single TCS, as well as a mutant lacking all 15 non-essential TCS. This powerful and unique genetic resource will allow us to unambiguously determine the contribution that each individual TCS to the regulation of peptidoglycan biosynthesis and antibiotic resistance.

Universidad Pública de Navarra
Campus de Arrosadía - 31006 Pamplona
Pamplona
Tel. 948 169000
Fax. 948 169169
Contacto por email
Campus de Tudela
Avda. de Tarazona s/n
31500 Tudela
Tel. (+34) 948 417800
Fax. (+34) 948 417892
Contacto por email