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Personal Docente e Investigador

Portada/ Personal Docente e Investigador



IÑIGO LASA UZCUDUN

Catedrático Universidad

  • CIENCIAS DE LA SALUD
  • Microbiología

  INSTITUTO DE AGROBIOTECNOLOGIA

e-mail: ilasaATunavarra.es

Teléfono: (+34) 948 16 9000

Current position:   Director of Navarrabiomed, Center of Biomedical Research, Pamplona. Spain

Education and past positions

  • 1983-1988       B.Sc. Biology. University of Navarra. Spain
  • 1992               PhD thesis in Science, Universidad Autonoma de Madrid.     
  • 1995-1997       EU Postdoctoral fellow.Unité des interactions Bacteries-Celules. Institut Pasteur. France.
  • 1998 – 2008     Assistant Professor of Microbiology. Universidad Pública de Navarra 
  • 2008-present   Professor of Microbiology. Universidad Pública de Navarra.

Scientific Expertise

  • Editorial board of Molecular Microbiology (2008-2010)
  • Head of the Management Board (MB) of the Biotechnology grant program of the Spanish Ministry
  • Visiting scientist. Cold Spring Harbor Laboratory. USA

Distinctions, Prices 

2001 “Ortiz de Landazuri” award. Gobierno de Navarra, Spain

2005 “Jaime Ferran” award. Sociedad Española de Microbiología. Cáceres. Spain

2006 Research award on Basic Science of the Public University of Navarra. Spain

Five selected publications (Members of the team are underlined)

  • Formosa-Dague C, Feuillie C, Beaussart A, Derclaye S, Kucharíková S, Lasa I, Van Dijck P, Dufrêne YF. 2016. Sticky Matrix: Adhesion Mechanism of the Staphylococcal Polysaccharide Intercellular Adhesin. ACS Nano 10:3443–3452.
  • Taglialegna A, Navarro S, Ventura S, Garnett JA, Matthews S, Penadés JR, Lasa I*,Valle J*. 2016. Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals. PLoS Pathog 12:e1005711.
  • Echeverz M, García B, Sabalza A, Valle J, Gabaldón T, Solano C, Lasa I. (2017). Lack of the PGA exopolysaccharide in Salmonellaas an adaptive trait for survival in the host. PLoS Genetics 13:e1006816.
  • Caballero CJ, Menendez-Gil P, Catalan-Moreno A, Vergara-Irigaray M, García B, Segura V, Irurzun N, Villanueva M, de Los Mozos IR, Solano C, Lasa I, Toledo-Arana A. 2018. The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus. Nucleic Acids Res 46:1345–1361.
  • Villanueva M, García B, Valle J, Ruiz de los Mozos I., Solano C, Marti M., Penades J.R., Toledo-Arana A., Lasa I.(2018). Sensory deprivation in Staphylococcus aureusNature Communications 9:523.

Bibliometrics figures (h index citations) ORCID:  0000-0002-6625-9221, Research ID: F-2947-2011

·     Total articles in publication list: 102

·     Articles with citation data: 91

·     Sum of the times cited: 5750

·     Average citations per article: 63

·     h-index: 44

·     Last updated: 02/20/2018

Research interests 

Our laboratory investigates fundamental mechanisms of regulation of bacterial biofilm development with a focus on human pathogens. We are interested in understanding how signal transduction systems control the transition between planktonic and sessile lifestyles. We also study the composition of biofilm matrix and the function of these compounds during infection. In particular, we do research on basic principles of RNA overlapping transcription and its role in gene expression, on mechanisms of exopolysaccharide synthesis regulation and on how surface proteins of the biofilm matrix mediated intercellular adhesion and interactions with the host cells. Very recently, we have deconstructed the two-component signal transduction system of Staphylococcus aureus. In this study, we have generated fifteen S. aureusstrains, each containing just a single TCS, as well as a mutant lacking all 15 non-essential TCS. This powerful and unique genetic resource will allow us to unambiguously determine the contribution that each individual TCS to the regulation of peptidoglycan biosynthesis and antibiotic resistance.


Universidad Pública de Navarra
Campus de Arrosadía - 31006 Pamplona
Pamplona
Tel. 948 169000
Fax. 948 169169
Contacto por email

Campus de Tudela
Avda. de Tarazona s/n
31500 Tudela
Tel. (+34) 948 417800
Fax. (+34) 948 417892
Contacto por email