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Viernes 24 de febrero de 2017

Conclusiones conferencia Aurelién Trivella

Por INAMAT

Los residuos farmacológicos son especialmente preocupantes debido por un lado a su continua introducción en el medio ambiente principalmente a través de los efluentes de plantas de tratamiento de aguas residuales y por otro a la toxicidad confirmada de algunos de ellos. Para evaluar el impacto ambiental de un compuesto farmacéutico, es esencial la caracterización de los productos de degradación derivados de procesos bióticos y abióticos (hidrólisis, fotólisis ...). En este contexto, Aurélien Trivella nos presentó ayer día 23 de Febrero en el marco de la conferencia titulada "Photodegradation of novel oral anticoagulants in surface waters", un estudio sobre la estabilidad de estas sustancias en matrices acuosas bajo irradiación solar y como son las estructuras derivadas del proceso.

Conferencia Aurelien Trivella
De izq a dcha: Iñaki Pérez de Landazabal (Director del INAMAT), Aurelién Trivella y Jesús Echeverría (Subdirector del INAMAT).

Conferencia

Drug residues are of particular concern due to their continuous introduction into the environment mainly through effluents of wastewater treatment plants and the confirmed toxicity of some of them. In the aim to evaluate the environmental impact of a pharmaceutical compound, the characterization of structures of degradation products derived from biotic and abiotic (hydrolysis, photolysis…) processes is essential.

The U.S. Food and Drug Administration (F.D.A.) recently approved the use of novel oral anticoagulants (NOACs), namely dabigatran etexilate (2010), rivaroxaban (2011), and apixaban (2012). In particular, two of these NOACs currently represent 30% of ingested anticoagulants in France with an increase of the consumption of a factor 10 between the second trimester 2012 and the third trimester 2013.

To our knowledge, information reported in the literature about the occurrence of NOACs in the aquatic compartment, about their fates, and about their toxicity and those of their degradation products are very scarce. This is especially troubling since human metabolism studies show that NOACs are eliminated in urines as unchanged forms at levels between 20 and 85% of the delivered dose. In this framework, the presented study answers the following questions:

  • - What is the stability of NOACs in aqueous matrices under simulated solar light irradiation?
  • - What are the structures of degradation products?

CV Aurelién Trivella

Aurélien TRIVELLA is lecturer at the Universitary Institute of Technology of Bordeaux and a member of EPOC-LPTC team since 2013. His research activities are currently centered on the abiotic processes of degradation of organic contaminants in surface waters and especially on photodegradation.



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