|Course code: 501005||Subject title: MOLECULAR FARMING: PLANTS AS BIOFACTORIES|
|Credits: 3||Type of subject: Optative||Year: 4||Period: 1º S|
|Department: Agronomía, Biotecnología y Alimentación|
|VERAMENDI CHAROLA, JON MIRENA (Resp)|
Biotechnology, transgenic plants, biopharmaceuticals, innovation
TC1: Ability to develop activities in the field of Rural and Agrifood Engineering, assuming a social, ethical, and environmental commitment.
TC2 Oral and written communication skills.
TC6 Ability to learn autonomously.
TC7 Ability to solve problems with creativity, initiative, methodology, and critical thinking.
SC12: Ability to recognize and utilize the base principles of animal production. Ability to define and design livestock facilities.
SC18: Ability to transfer technology; understand, interpret, communicate, and adopt advances in the field of agriculture.
R1- To know, understand and apply the molecular underpinnings and biotechnological techniques in the production of recombinant proteins in plants.
R2- To know the applications of the molecular farming
R3- To know the legal framework and biosecurity issues of products obtained by molecular farming
|Methodology - Activity||Classroom hours||Non-classroom hours|
|A-3 Debates, knowledge pooling, group mentoring|
|A-5 Reading Material||38|
|A-6 Personal study||15|
|A-7 Exams, assessment tests||2|
|A-8 Indivual mentoring|
|SC12||A1, A4, A5, A6|
|SC18||A1, A5, A7|
Knowledge of the basic concepts of the subject: answering of questionnaires for each of the presented topic (50%).
Preparation of a individual presentation on a scientific article (40%).
Participation in discussion forums and use of tutorials (10%).
Plants as chemical and pharmaceutical factories
Legal framework and biosecurity of molecular farming production.
0 - Transgenic plants: concept and methods of plant transformation.
1 - Plants as chemical and pharmaceutical factories: production of therapeutic proteins, antibodies, vaccines, enzymes and proteins of industrial use.
2 - Recommended crops on molecular farming: mono - or dicotyledons; annual or perennial; biomass index; production on leaf crops, seeds or fruits.
3 - Production technology: stable or transient expression; expression in nucleus or plastids; expression with viral vectors or agroinfiltracion; bioreactors; systems to optimize the expression of the transgene.
4 - Post-translational modifications of biopharmaceutical compounds produced in plants. Molecular farming and enterprise.
5 - Legal framework and biosecurity of molecular farming production.
Genoma España. Plantas biofactoría: informe de vigilancia tecnológica. 2005.
Christou P y Klee H. Handbook of plant biotechnology (volume 2). Editorial John Wiley and Sons, Ltd. 2004.
Erickson L, Yu WJ, Brandle J y Rymerson R. Molecular farming of plants and animals for human and veterinary medicine. Editorial Kluwer Academic Publishers. 2002.
Faye L y Gomord V. Recombinant proteins from plants. Editorial Humana Press. 2009.
Fischer R y Schillberg S. Molecular farming: plant-made pharmaceuticals and technical proteins. Editorial Wiley-VCH Verlag GmbH. 2004.
Hammond BG. Food safety of proteins in agricultural biotechnology. Editorial CRC Press. 2008.
Hood EE y Howard JA. Plants as factories for protein production. Editorial Kluwer Academic Publishers. 2002.
Walsh G. Biopharmaceuticals: biochemistry and biotechnology (2nd edition). Editorial John Wiley and Sons, Ltd. 2003.